Search results for " genistein"

showing 3 items of 3 documents

Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: Results from a pilot strain-echo study

2017

Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurement…

Cardiac function curvemedicine.medical_specialtycardiac function; echocardiography; genistein; menopause; metabolic syndromegenistein; metabolic syndrome; menopause; cardiac function; echocardiographyGenisteinlcsh:TX341-641030204 cardiovascular system & hematologyPlaceboArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDouble-Blind MethodInterquartile rangeInternal medicinemedicineHumans030212 general & internal medicineEnd-systolic volumeBody surface areaNutrition and DieteticsEjection fractionbusiness.industryCardiac functionHeartMiddle Agedmedicine.diseaseGenisteinMetabolic syndromePostmenopauseEndocrinologychemistryEchocardiographyDietary SupplementsCardiologyCardiac function; Echocardiography; Genistein; Menopause; Metabolic syndrome; Food ScienceFemaleMetabolic syndromeMenopausebusinesslcsh:Nutrition. Foods and food supplyFood Science
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Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense

2018

Curcumin and genistein are two natural products obtained from Curcuma longa L. and soybeans, endowed with many biological properties. Within the last years they were shown to possess also a promising antitrypanosomal activity. In the present paper, we investigated the activity of both curcumin and genistein against rhodesain, the main cysteine protease of Trypanosoma brucei rhodesiense; drug combination studies, according to Chou and Talalay method, allowed us to demonstrate a potent synergistic effect for the combination curcumin-genistein. As a matter of fact, with our experiments we observed that the combination index of curcumin-genistein is < 1 for the reduction from 10 to 90% of rhode…

Drugbiology010405 organic chemistryChemistrymedia_common.quotation_subjectOrganic Chemistryfood and beveragesGenisteinTrypanosoma brucei rhodesienseCombination indexPlant SciencePharmacologybiology.organism_classification01 natural sciencesBiochemistryCysteine protease0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistrychemistry.chemical_compoundBiological propertyCurcuminCurcumin genistein rhodesain drug combination studies synergismCurcumamedia_commonNatural Product Research
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Genistein and endothelial function in postmenopausal women with metabolic syndrome

2013

BackgroundPrevious data have suggested that genistein could exert beneficial effects on endothelial function and on predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the effects of genistein on endothelial function in postmenopausal women with metabolic syndrome (MS). MethodsTwenty postmenopausal women with MS, according to modified NCEP-ATP III criteria were randomly assigned to receive placebo or genistein (54mg/day) for 6months, along with a Mediterranean-style diet. Postmenopausal women without MS (n=15), served as controls. The primary goal was the assessment of endothelial function by flow-mediated vasodilation (FMD) of brach…

medicine.medical_specialtyHomocysteineClinical BiochemistryGenisteinmenopausePhytoestrogensPilot ProjectsVasodilationPlaceboBiochemistrymetabolic syndromeClinical studygenisteinchemistry.chemical_compoundendothelial functionmedicine.arteryInternal medicinemedicineHumansAnkle Brachial IndexBrachial arteryAdiponectinbusiness.industryClinical study; Endothelial function; Genistein; Menopause; Metabolic syndromeGeneral MedicineMiddle Agedmedicine.diseasePostmenopauseVasodilationMenopauseTreatment OutcomeEndocrinologychemistryFemaleEndothelium VascularMetabolic syndromebusiness
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